Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

NEDP1 (human), (recombinant) (His-tag)

BML-UW9770-0100 100 µg 290.00 USD
Do you need bulk/larger quantities?

Product Details

Alternative Name:NEDD8-specific protease 1, SENP8, Sentrin-specific protease 8, Deneddylase 1
Source:Produced in E. coli.
UniProt ID:Q96LD8
Formulation:Liquid. In 50mM TRIS-Cl, pH 7.7, containing 50% glycerol, 1mM DTT.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:NEDP1, a human NEDD8-specific protease, is highly conserved throughout evolution and equivalent proteins are present in yeast, plants, insects, and mammals. NEDP1 appears to be specific for NEDD8 as neither ubiquitin nor SUMO bearing COOH- terminal extensions are utilized as substrates. Inhibition studies and mutagenesis indicate that NEDP1 is a cysteine protease with sequence similarities to SUMO-specific proteases and the class of viral proteases typified by the adenovirus protease. in vivo NEDP1 deconjugates NEDD8 from a wide variety of substrates including the cullin component of SCF-like complexes. Thus NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes.
Regulatory Status:RUO - Research Use Only

Related Literature

Stem Cells
Stem Cells
Download as PDF

Ubiquitin & UBL Signaling Catalog
Ubiquitin & UBL Signaling Catalog
Download as PDF

All new literature pieces