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SENP1 (catalytic domain) (human), (recombinant) (GST-tag)

BML-UW9760-0100 100 µg 330.00 USD
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Product Details

Alternative Name:Sentrin-specific protease 1
Source:Produced in E. coli.
UniProt ID:Q9P0U3
Formulation:Liquid. In 50mM Tris, 150mM NaCl, pH 7.5, containing 0.5mM DTT.
Biological Activity:This fragment has full de-SUMOylating activity.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:SENP1 fragment has been reported to co-localize with a herpes virus protein ICP0 during early infection. This co-localization may be involved in the ICP0-induced loss of SUMO-1-modified PML in infected cells. Characterization of the localization and regulation of SENP1 has also been reported. SENP1 localization may also be influenced by the expression of proteins that are targets of SUMO-1 modification, such as HDAC4 and PML, which affect the relative levels and localization of SUMO-1 conjugates within the cell.
Regulatory Status:RUO - Research Use Only

Product Literature References

Epigenetic regulation of HDAC1 SUMOylation as an endogenous neuroprotection against Aβ toxicity in a mouse model of Alzheimer's disease: C.C. Tao, et al.; Cell Death Differ. 24, 597 (2017), Abstract; Full Text
Smad4 SUMOylation is essential for memory formation through upregulation of the skeletal myopathy gene TPM2: W.L. Hsu, et al.; BMC Biol. 15, 112 (2017), Application(s): In vitro SUMOylation assay, Abstract; Full Text
Chemotherapeutic sensitivity of testicular germ cell tumors under hypoxic conditions is negatively regulated by SENP1-controlled sumoylation of OCT4: Y.C. Wu, et al.; Cancer Res. 72, 4963 (2012), Abstract; Full Text

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