Ubiquitin-conjugating DNA repair enzyme.
Product Specification
| Alternative Name: | UbcH2B, Ubiquitin conjugating enzyme E2 B |
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| MW: | 17.3 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P63146 |
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| Formulation: | Liquid. In 50mM HEPES, pH 8.0, 50mM NaCl, 10% glycerol, 1mM DTT. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | The family of UBC enzymes plays a central role in the ubiquitin pathway. Genetic studies with the S. cerevisiae Rad6 protein demonstrate a pleiotropic phenotype, including defects in DNA repair, proteolysis of N-end rule protein substrates, cellular proliferation, cell cycle progression and an inability to sporulate , which are all dependent on its ubiquitin-conjugating activity. In mice and humans, two homologues of RAD6 have been identified - hHR6A (homologue of RAD6A) and hHR6B (homologue of RAD6B) . Inactivation of the hHR6B-homologous gene in mice causes male infertility, which strongly implicates hHR6-dependent ubiquitinylation in chromatin remodeling. |
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| Regulatory Status: | RUO - Research Use Only |
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