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Ubiquitin (human), (recombinant)

BML-UW8795-0005 5 mg 110.00 USD
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Product Details

MW:8565 Da
Source:Produced in E. coli.
UniProt ID:P0CG47 (UBB), P0CG48 (UBC), P62979 (RPS27A), P62987 (UBA52)
Purity:≥98% (SDS-PAGE)
Appearance:White powder.
Solubility:Soluble in water
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:Ubiquitin is a 76 amino acid protein,which when covalently linked to proteins as a branched chain, serves as a tag marking proteins for a variety of cellular activities. Its primary sequence is remarkably conserved, with only three amino acid changes between the yeast and human sequences. Originally isolated from thymus and assumed to be a thymic hormone its primary role is now recognised as being in ATP-dependent protein degradation.
Regulatory Status:RUO - Research Use Only

Product Literature References

Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL: M. Hussein, et al.; STAR Protoc. 3, 101710 (2022), Abstract;
Biophysical and biological evaluation of optimized stapled peptide inhibitors of the linear ubiquitin chain assembly complex (LUBAC): F. Aguilar-Alonso, et al.; Bioorg. Med. Chem. 26, 1179 (2018), Abstract;
BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor: R. Priyadarshini, et al.; Cell Rep. 24, 947 (2018), Abstract;
The Monocot-Specific Receptor-like Kinase SDS2 Controls Cell Death and Immunity in Rice: J. Fan, et al; Cell Host Microbe 23, 498 (2018), Abstract; Full Text
BubR1 Promotes Bub3-Dependent APC/C Inhibition during Spindle Assembly Checkpoint Signaling: K. Overlack, et al.; Curr. Biol. 27, 2915 (2017), Abstract; Full Text
Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability: S.S. Kharat, et al.; Oncogene 35, 125 (2016), Application(s): In vitro ubiquitylation, Abstract;
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7: Y. Liu, et al.; Cell Death Dis. 6, e1630 (2015), Application(s): Assay, Abstract; Full Text
Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF182: S.M. Pedersen, et al.; Mol. Cell. Biol. 36, 794 (2015), Abstract; Full Text
Pro-apoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin: Y. Liu, et al.; J. Biol. Chem. 290, 11843 (2015), Application(s): Assay, Abstract; Full Text
The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy: D.A. Tumbarello, et al.; PLoS One 11, e1005174 (2015), Application(s): Western Blot, Abstract; Full Text
UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP: Y. Teng, et al.; Biochem. Pharmacol. 97, 518 (2015), Application(s): Western Blot, Abstract;
Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS): J.E. Gilda, et al.; PLoS One 10, e0135392 (2015), Abstract; Full Text
The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR: L. Zhou, et al.; PLoS One 6, e23936 (2011), Abstract; Full Text
The ubiquitin system: A. Hershko et al.; Annu. Rev. Biochem. 67, 425 (1998), Abstract;
Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells: G. Goldestein et al.; PNAS 72, 11 (1975), Abstract;

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