Product Details
| Alternative Name: | Small ubiquitin-related modifier 4 |
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| MW: | ~12.5kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | Q6EEV6 |
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| Formulation: | Liquid. In 20mM HEPES, pH 8.0, containing 1mM DTT. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Purity Detail: | Purified by multistep chromatography. |
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| Application Notes: | For use in SUMO-4 conjugation studies. |
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| Shipping: | Shipped on Dry Ice |
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| Short Term Storage: | -80°C |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 12 months after receipt when stored at -80°C. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
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| Scientific Background: | SUMO-4 is a member of the SUMO (small ubiquitin-related modifier) family of ubiquitin-like proteins involved in the regulation of the cellular functions of a wide variety of proteins, although there remains considerable debate as to whether this is a real and expressed gene product.
It has been reported that upon oxidative stress, SUMO-4 conjugates to various anti-oxidant enzymes, chaperones, and stress defence proteins, whereas under standard physiological conditions it is rapidly degraded. Subsequent proteomic analysis of SUMO-4 conjugates identified substrates implicated in the regulation of DNA repair and synthesis, RNA processing, protein degradation and glucose metabolism, suggesting a role for SUMO-4 in the regulation of intracellular stress.
The M55V substitution in SUMO-4 has been associated with type I diabetes. |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE image of His6-SUMO4 (1.5µg, BML-UW0905), coomassie stained.
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General Literature References
A stress-dependent SUMO4 sumoylation of its substrate proteins: W. Wei, et al.; BBRC
375, 454 (2008),
Abstract;
SUMO4 and its role in type 1 diabetes pathogenesis: C.Y. Wang & J.X. She; Diabetes Metab. Res. Rev.
24, 93 (2008),
Abstract;
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress: D. Guo, et al.; BBRC
337, 1308 (2005),
Abstract;
SUMO, ubiquitin's mysterious cousin: S. Muller, et al.; Nat. Rev. Mol. Cell Biol.
2, 202 (2001),
Abstract;
