NEDD8-AMC is a fluorogenic substrate for deNEDDylating enzymes, including NEDP1 and UCH-L3. It is a particularly useful reagent for the study of deNEDDylating activity where detection sensitivity or continuous monitoring of activity is essential.
Product Details
| MW: | 8.735 kDa |
| |
| Source: | Produced in E. coli. |
| |
| UniProt ID: | Q15843 |
| |
| Concentration: | 1 mg/ml |
| |
| Formulation: | Solution in DMSO. |
| |
| Purity: | ≥95% (HPLC) |
| |
| Appearance: | Liquid. |
| |
| Application Notes: | Uses:
1. Substrate for deNEDDylating enzyme activity assays.
2. Identification/confirmation of enzyme deNEDDylation activity.
3. Investigation of deconjugating enzyme substrate specificity in comparison with alternative UBL-AMC substrates (e.g. Ubiquitin-AMC, Prod. No. BML-SE211). |
| |
| Shipping: | Dry Ice |
| |
| Long Term Storage: | -80°C |
| |
| Handling: | Avoid freeze/thaw cycles. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
A family of unconventional deubiquitinases with modular chain specificity determinants: T. Hermanns, et al.; Nat. Commun.
9, 799 (2018),
Abstract;
Full Text
Related Products
