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Ultra-pure; stabilizes microtubules
BML-T129-0005 5 mg 102.00 USD
BML-T129-0025 25 mg 440.00 USD
BML-T129-0250 250 mg 1,497.00 USD
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Docetaxel is taxane-type antineoplastic agent structurally similar to taxol. It reversibly binds to polymerized tubulin inhibiting depolymerization. It induces apoptosis in a large number of tumor cells and is a clinically important anticancer agent.

Product Details

Alternative Name:Taxotere
Purity:≥98% (HPLC)
Appearance:White solid.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
BML-T129 structure
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BML-T129 structure

Product Literature References

Macrophage secretory IL-1β promotes docetaxel resistance in head and neck squamous carcinoma via SOD2/CAT ICAM1 signalin: C.Y Hsieh, et al.; JCI Insight 7, e157285 (2022), Abstract;
Docetaxel facilitates lymphatic-tumor crosstalk to promote lymphangiogenesis and cancer progression: A.R. Harris, et al.; BMC Cancer 18, 718 (2018), Abstract; Full Text
Direct modification of the 5-HT3 receptor current by some anticancer drugs: Y. Nakamura, et al.; Eur. J. Pharmacol. 821, 21 (2017), Abstract;
Docetaxel in the management of prostate cancer: current standard of care and future directions: S. De Dosso & D.R. Berthold; Expert. Opin. Pharmacother. 9, 1969 (2008), Abstract;
Mitotic catastrophe and apoptosis induced by docetaxel in hormone-refractory prostate cancer cells: F. Fabbri, et al.; J. Cell Physiol. 217, 494 (2008), Abstract;
Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines: M.D. Kars, et al.; Chemotherapy 54, 194 (2008), Abstract;
RPN2 gene confers docetaxel resistance in breast cancer: K. Honma, et al.; Nat. Med. 14, 939 (2008), Abstract;
Sunitinib malate (SU-11248) alone or in combination with low-dose docetaxel inhibits the growth of DU-145 prostate cancer xenografts: A. Cumashi, et al.; Cancer Lett. 270, 229 (2008), Abstract;

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