Replaces Prod. #: ALX-350-130
Inhibits actin polymerization, microfilament organzation and microfilament-mediated processes. Acts via a different mechanism and 10- to 20-fold more potently than cytochalasins. Inhibits phagocytosis by macrophages. Exposure to 0.2 mg/ml for one hour produces maximal change in cell morphology.
Product Details
| Formula: | C22H31NO5S |
| |
| MW: | 421.6 |
| |
| CAS: | 76343-93-6 |
| |
| MI: | 14: 5378 |
| |
| Purity: | ≥95% (HPLC) |
| |
| Appearance: | White to yellow waxy solid. |
| |
| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
| |
| Handling: | Protect from light. |
| |
| Technical Info/Product Notes: | Note: Product is not sterile. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis: T. Mentrup, et al.; Nat. Commun.
13, 1880 (2022),
Abstract;
Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and Vop: E. Kudryashova, et al.; Sci. Adv.
8, eadc9239 (2022),
Abstract;
Genetic Suppression of Defective Profilin by Attenuated Myosin II Reveals a Potential Role for Myosin II in Actin Dynamics in vivo in fission yeast: P. Zambon, et al.; Mol. Biol. Cell
31, 2107 (2020),
Abstract;
Full Text
Calcium-mediated actin reset (CaAR) mediates acute cell adaptations: P. Wales, et al.; eLife
5, e19850 (2016),
Abstract;
Full Text
GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation: N. Fine, et al.; J. Cell. Biol.
215, 107 (2016),
Application(s): Cell treatment, mouse neutrophils,
Abstract;
Full Text
Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One
10, e0125119 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep.
5, 9475 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking: F. O. Bendezú, et al.; PLoS One
31, e1002097 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel: H. Sun, et al.; Sci. Rep.
4, 4934 (2014),
Abstract;
Full Text
Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment: W. Nimlamool, et al.; Mol. Reprod. Dev.
80, 488 (2013),
Abstract;
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One
8, e72886 (2013),
Abstract;
Full Text
The nucleus of endothelial cell as a sensor of blood flow direction: E. Tkachenko, et al.; Biol. Open
2, 1007 (2013),
Abstract;
Full Text
A role for hippocampal actin rearrangement in object placement memory in female rats: B.S. Nelson, et al.; Neurobiol. Learn. Mem.
98, 284 (2012),
Abstract;
Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins: F.Y. Shaikh, et al.; PLoS One
7, e40826 (2012),
Abstract;
Full Text
Glioblastoma motility occurs in the absence of actin polymer: A. Panopoulos, et al.; Mol. Biol. Cell
22, 2212 (2011),
Abstract;
Full Text
Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK: P. Qiu, et al.; FASEB J.
25, 1815 (2011),
Abstract;
Full Text
Regulation of Distinct Septin Rings in a Single Cell by Elm1p and Gin4p Kinases: B.S. DeMay, et al.; Mol. Biol. Cell
20, 2311 (2009),
Abstract;
Latrunculin A depolarizes starfish oocytes: F. Moccia; Comp. Biochem. Physiol. A Mol. Integr. Physiol.
148, 845 (2007),
Abstract;
Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis: J. Wang, et al.; Cell Motil. Cytoskeleton
62, 35 (2005),
Abstract;
Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A: A. Vazquez-Lopez; Neurosci. Lett.
388, 81 (2005),
Abstract;
The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae: F. Reggiori, et al.; Mol. Biol. Cell
16, 5843 (2005),
Abstract;
High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A: K.R. Ayscough, et al.; J. Cell Biol.
137, 399 (1997),
Abstract;
Full Text
Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton
13, 127 (1989),
Abstract;
Latrunculin A is a potent inhibitor of phagocytosis by macrophages: C.A. de Oliveira and B. Mantovani; Life Sci.
43, 1825 (1988),
Abstract;
Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett.
213, 316 (1987),
Abstract;
Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res.
166, 191 (1986),
Abstract;
Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science
219, 493 (1983),
Abstract;
General Literature References
Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),
