Replaces Prod. #: ALX-350-130
Inhibits actin polymerization, microfilament organzation and microfilament-mediated processes. Acts via a different mechanism and 10- to 20-fold more potently than cytochalasins. Inhibits phagocytosis by macrophages. Exposure to 0.2 mg/ml for one hour produces maximal change in cell morphology.
Product Details
| Formula: | C22H31NO5S |
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| MW: | 421.6 |
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| CAS: | 76343-93-6 |
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| MI: | 14: 5378 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to yellow waxy solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Calcium-mediated actin reset (CaAR) mediates acute cell adaptations: P. Wales, et al.; eLife
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GEF-H1 is necessary for neutrophil shear stress-induced migration during inflammation: N. Fine, et al.; J. Cell. Biol.
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Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo: T. Chimura, et al.; PLoS One
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Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury: T. Grevesse, et al.; Sci. Rep.
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Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking: F. O. Bendezú, et al.; PLoS One
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Label-free cell phenotypic profiling decodes the composition and signaling of an endogenous ATP-sensitive potassium channel: H. Sun, et al.; Sci. Rep.
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Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment: W. Nimlamool, et al.; Mol. Reprod. Dev.
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Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One
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The nucleus of endothelial cell as a sensor of blood flow direction: E. Tkachenko, et al.; Biol. Open
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A role for hippocampal actin rearrangement in object placement memory in female rats: B.S. Nelson, et al.; Neurobiol. Learn. Mem.
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Respiratory syncytial virus assembles into structured filamentous virion particles independently of host cytoskeleton and related proteins: F.Y. Shaikh, et al.; PLoS One
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Glioblastoma motility occurs in the absence of actin polymer: A. Panopoulos, et al.; Mol. Biol. Cell
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Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK: P. Qiu, et al.; FASEB J.
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Regulation of Distinct Septin Rings in a Single Cell by Elm1p and Gin4p Kinases: B.S. DeMay, et al.; Mol. Biol. Cell
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Latrunculin A depolarizes starfish oocytes: F. Moccia; Comp. Biochem. Physiol. A Mol. Integr. Physiol.
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Differential effects of latrunculin-A on myofibrils in cultures of skeletal muscle cells: Insights into mechanisms of myofibrillogenesis: J. Wang, et al.; Cell Motil. Cytoskeleton
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Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A: A. Vazquez-Lopez; Neurosci. Lett.
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The actin cytoskeleton is required for selective types of autophagy, but not nonspecific autophagy, in the yeast Saccharomyces cerevisiae: F. Reggiori, et al.; Mol. Biol. Cell
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High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A: K.R. Ayscough, et al.; J. Cell Biol.
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Latrunculins--novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton
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Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett.
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Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res.
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General Literature References
Makrolide aus marinen Organismen: G. Schilling; Labor&more 1.12, 32 (2012),
