Replaces Prod. #: ALX-430-037
Potent antineoplastic activity. Inhibits polyamine synthesis and the synthesis of mitochnondrial DNA.
Product Specification
| Formula: | C14H34N4 . 4HCl |
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| MW: | 404.3 |
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| CAS: | 113812-15-0 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White crystalline solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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Product Literature References
Selective cellular depletion of mitochondrial DNA by the polyamine analog N1,N12-bis(ethyl)spermine and its relationship to polyamine structure and function: P.M. Vertino, et al.; Mol. Pharmacol.
39, 487 (1991),
Abstract;
Combined regulation of ornithine and S-adenosylmethionine decarboxylases by spermine and the spermine analogue N1 N12-bis(ethyl)spermine: C.W. Porter, et al.; Biochem. J.
268, 207 (1990),
Abstract;
High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma: R.A. Casero Jr., et al.; Biochem. J.
270, 615 (1990),
Abstract;
Full Text
Regulation of ornithine decarboxylase activity by spermidine and the spermidine analogue N1N8-bis(ethyl)spermidine: C.W. Porter, et al.; Biochem. J.
242, 433 (1987),
Abstract;
Relative abilities of bis(ethyl) derivatives of putrescine, spermidine, and spermine to regulate polyamine biosynthesis and inhibit L1210 leukemia cell growth: C.W. Porter, et al.; Cancer Res.
47, 2821 (1987),
Abstract;
