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U-73343

Phospholipase inhibitor
 
BML-ST392-0005 5 mg 99.00 USD
 
BML-ST392-0025 25 mg 385.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-370-006

Inactive analog of U-73122 (Prod. No. BML-ST391) which only slightly inhibits phospholipase C. May be used as a negative control.

Product Specification

Alternative Name:1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-pyrrolidine-2,5-dione
 
Formula:C29H42N2O3
 
MW:466.7
 
CAS:142878-12-4
 
Purity:≥98% (HPLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in methylene chloride or chloroform; slightly soluble in DMSO (2mg/ml) or 100% ethanol (1mg/ml); sparingly soluble in aqueous solutions.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Effect of selective serotonin (5-HT)2B receptor agonist BW723C86 on epidermal growth factor/transforming growth factor-α receptor tyrosine kinase and ribosomal p70 S6 kinase activities in primary cultures of adult rat hepatocytes: K. Naito, et al.; Biol. Pharm. Bull. 42, 631 (2019), Application(s): used w. adult rat liver hepatocytes, Abstract; Full Text
Comparative Effects of the Endogenous Agonist Glucagon-Like Peptide-1 (GLP-1)-(7-36) Amide and the Small-Molecule Ago-Allosteric Agent "Compound 2" at the GLP-1 Receptor: K. Coopman, et al.; J. Pharmacol. Exp. Ther. 334, 795 (2010), Application(s): IP of human embryonic kidney cells, Abstract; Full Text
U-73122, a phospholipase C antagonist, inhibits effects of endothelin-1 and parathyroid hormone on signal transduction in UMR-106 osteoblastic cells: A. Tatrai, et al.; Biochim. Biophys. Acta 1224, 575 (1994), Abstract;
A new, nongenomic estrogen action: the rapid release of intracellular calcium: P Morley, et al.; Endocrinology 131, 1305 (1992), Abstract;
Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production: B.E. Hawes, et al.; Endocrinology 130, 3475 (1992), Abstract;
Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness: R.J. Smith, et al.; J. Pharmacol. Exp. Ther. 253, 688 (1990), Abstract;

Related Products

U-73122 

Inhibitor of PLC activation
112648-68-7, ≥98% (HPLC) | Print as PDF
 
BML-ST391-0005 5 mg 100.00 USD
 
BML-ST391-0025 25 mg 396.00 USD
Do you need bulk/larger quantities?
 

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