Dual phospholipase D1/D2 (PLD1/PLD2) inhibitor in cellular assays (PLD1 IC50=8nM in Calu-1 cells; PLD2 IC50=42nM in HEK293-gfpPLD2 cells).
Product Details
| Alternative Name: | N-[(1-[4-(2-Oxo-3H-benzimidazol-1-yl)-piperidin-1-yl]-ethyl]quinoline-3-carboxamide |
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| Formula: | C24H25N5O2 |
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| MW: | 415.5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity: J.A. Lewis, et al.; Bioorg. Med. Chem. Lett.
19, 1916 (2009),
Abstract;
