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BML-280

PLD inhibitor
 
BML-ST371-0005 5 mg 94.00 USD
 
BML-ST371-0025 25 mg 303.00 USD
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Potent and selective inhibitor of phospholipase D2 (PLD2) in cellular (PLD1 IC50 = 1900nM Calu-1 cells; PLD2 IC50 = 90nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC50 = >20’000nM; hPLD2 IC50 = 500nM) assays.

Product Specification

Alternative Name:N-(2-(4-Oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)quinoline-3-carboxamide, VU0285655-1
 
Formula:C25H27N5O2
 
MW:429.5
 
CAS:1158347-73-9
 
Purity:≥98% (TLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity: R. Lavieri, et al.; Bioorg. Med. Chem. Lett. 19, 2240 (2009), Abstract;

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