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VU0155069

PLD inhibitor
 
BML-ST370-0005 5 mg 99.00 USD
 
BML-ST370-0025 25 mg 357.00 USD
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Potent and specific inhibitor of phospholipase D1 (PLD1) in cellular (PLD1 IC50 = 11nM Calu-1 cells; PLD2 IC50 = 1800nM HEK293-gfpPLD2 cells) and in vitro (hPLD1 IC50 = 46nM; hPLD2 IC50 = 933nM) assays. Significantly decreases invasive migration in breast cancer cell lines (MDA-231, 4T1 and PMT).

Product Specification

Alternative Name:N-[(2S)-1-[4-(5-Chloro-2-oxo-3H-benzimidazol-1-yl)-piperidin-1-yl]-propan-2-yl]naphthalene-2-carboxamide
 
Formula:C26H27ClN4O2
 
MW:463.0
 
CAS:1130067-06-9
 
Purity:≥98% (TLC)
 
Appearance:Pale-yellow solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness: S.A. Scott, et al.; Nat. Chem. Biol. 5, 108 (2009), Abstract;

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