Replaces Prod. #: ALX-340-017
Selective, active-site directed, irreversible inhibitor of cPLA2 (IC50=5µM) and Ca2+-independent iPLA2 (IC50=0.5µM). Potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH) (IC50=2.5nM), 800 -fold more potent than AACOCF3 (Prod. No. BML-ST335)). Irriversible CB1 receptor antagonist in rat brain membrane (IC50=20nM).
Product Details
| Alternative Name: | MAFP, Methylphosphonofluoridic acid 5,8,11,14-eicosatetraenyl ester |
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| Formula: | C21H36FO2P |
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| MW: | 370.5 |
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| CAS: | 188404-10-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Colorless to yellow oil. |
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| Solubility: | Soluble in 100% ethanol (50mg/ml) or DMSO (50mg/ml). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -80°C. Stock solutions are stable for up to 2 months at -20°C. |
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| Handling: | Protect from air. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist: S.R. Fernando & R.G.Pertwee; Br. J. Pharmacol.
121, 1716 (1997),
Abstract;
Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase: D.G. Deutsch, et al.; Biochem. Pharmacol.
53, 255 (1997),
Abstract;
Distinct roles in signal transduction for each of the phospholipase A2 enzymes present in P388D1 macrophages: J. Balsinde & E.A. Dennis; J. Biol. Chem.
271, 6758 (1996),
Abstract;
Full Text
Irreversible inhibition of Ca(2+)-independent phospholipase A2 by methyl arachidonyl fluorophosphonate: Y.C. Lio, et al.; Biochim. Biophys. Acta
1302, 55 (1996),
Abstract;
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