HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).
Product Details
| Alternative Name: | Haloenol lactone suicide substrate |
| |
| Formula: | C16H13BrO2 |
| |
| MW: | 317.2 |
| |
| CAS: | 88070-98-8 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | White solid. |
| |
| MeltingPoint: | 104-106°C |
| |
| Solubility: | Soluble in DMSO (25mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions under at atmosphere of argon or nitrogen at -20°C for up to 1 month. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
