Replaces Prod. #: ALX-350-038
Marine sesterterpenoid. Structurally related to manoalide (Prod. No. BML-EI177). Anti-inflammatory phospholipase A2 (PLA2) inhibitor (IC50=0.23µM). Less potent than manoalide, but partially reversible (IC50=0.23µM, bee venom PLA2). Inhibits human recombinant sPLA2 (IC50=9.3µM) selectively over cPLA2.
Product Details
| Formula: | C25H38O3 |
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| MW: | 386.6 |
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| Source: | Isolated from sponge Luffariella sp. |
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| CAS: | 111149-87-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Pale yellow oil. |
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| Solubility: | Soluble in DMSO or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Technical Info/Product Notes: | Note: Product is not sterile |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization and pharmacological modulation of soluble phospholipase A2 generated during glycogen-induced rat peritonitis: L.A. Marshall, et al.; Agents Actions
37, 60 (1992),
Abstract;
PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase: K.B. Glaser, et al.; Agents Actions
34, 89 (1991),
Abstract;
Luffariellolide, an anti-inflammatory sesterterpene from the marine sponge Luffariella spp.: K.F. Albizati, et al.; Experientia 43, 949 (1987),
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