Novel inhibitor of Bcl-XL that induces autophagic cell death in HeLa cells. The first small molecule inhibitor of Bcl-XL that induces autophagic cancer cell death independent of apoptosis and is, thus, an important new tool for studying the cellular regulation of autophagy and apoptosis.
Product Specification
| Alternative Name: | (Z)-5-Fluoro-1-(3'-dimethylamino)propyl-3-[(5'-methoxyindol-3-ylidene)methyl]-indolin-2-one |
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| Formula: | C23H24FN3O2 |
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| MW: | 393.5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Yellow solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml). |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in HeLa cells: J. Lin, et al.; Autophagy
5, 314 (2009),
Abstract;
