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United States 

Bryostatin 1

PKC activator
BML-ST103-0010 10 µg 360.00 USD
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A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε.

Product Details

Purity:≥98% (HPLC)
Appearance:White solid to colorless film.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-ST103 structure
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BML-ST103 structure

Product Literature References

Combined single-cell transcriptional, translational, and genomic profiling reveals HIV-1 reservoir diversity: G. Sannier, et al.; Cell Rep. 36, 109643 (2021), Abstract;
APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes: A.O. Giarratana, et al.; Sci. Rep. 10, 19919 (2020), Abstract; Full Text
Differential regulation of protein kinase C isozymes by bryostatin 1 and phorbol 12-myristate 13-acetate in NIH 3T3 fibroblasts: Z. Szallasi, et al.; J. Biol. Chem. 269, 2118 (1994), Abstract;
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin: H. Hennings, et al.; Carcinogenesis 8, 1343 (1987), Abstract;