A structurally unique marine natural product that binds to and activates PKC at picomolar concentrations, but is not a carcinogen or a complete tumor promoter. In many systems it induces only a subset of the responses to PMA and blocks those which it does not induce. It is markedly more potent than PMA for translocating PKCδ and -ε.
Product Details
| Formula: | C47H68O17 |
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| MW: | 905.0 |
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| CAS: | 83314-01-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid to colorless film. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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APOE4 genetic polymorphism results in impaired recovery in a repeated mild traumatic brain injury model and treatment with Bryostatin-1 improves outcomes: A.O. Giarratana, et al.; Sci. Rep.
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Abstract;
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269, 2118 (1994),
Abstract;
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin: H. Hennings, et al.; Carcinogenesis
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Abstract;
