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N-Oleylethanolamide

TRPV1 activator



BML-SL231-0010	10 mg	75.00 USD

BML-SL231-0050	50 mg	312.00 USD
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Replaces Prod. #: ALX-300-150

Activates TRPV1. Endogenous anandamide-like lipid which regulates appetite but does not bind to cannabinoid receptors. In rats, food intake is inhibited by oral oleylethanolamide. Induces satiety by activation of PPARα. Inhibits ceramidase.

Product Details

Formula:	C₂₀H₃₉NO₂

MW:	325.5

CAS:	111-58-0

Purity:	≥98% (TLC)

Appearance:	White solid.

Solubility:	Soluble in DMSO (>25mg/ml), methanol or 100% ethanol (>25mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Food intake is inhibited by oral oleoylethanolamide: M.J. Nielsen, et al.; J. Lipid Res. 45, 1027 (2004), Abstract;

Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor alpha (PPAR-alpha): M. Guzman, et al.; J. Biol. Chem. 279, 27849 (2004), Abstract;

Activation of TRPV1 by the satiety factor oleoylethanolamide: G.P. Ahern; J. Biol. Chem. 278, 30429 (2003), Abstract;

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha: J. Fu, et al.; Nature 425, 90 (2003), Abstract;

A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding: R. Gomez, et al.; J. Neurosci. 22, 9612 (2002), Abstract;

An anorexic lipid mediator regulated by feeding: F. Rodriguez de Fonseca, et al.; Nature 414, 209 (2001), Abstract;

Anti-immunoglobulin-induced apoptosis in WEHI 231 cells involves the slow formation of ceramide from sphingomyelin and is blocked by bcl-XL: D.A. Wiesner, et al.; J. Biol. Chem. 272, 9868 (1997), Abstract;

Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995), Abstract;

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation: E. Coroneos, et al.; J. Biol. Chem. 270, 23305 (1995), Abstract;

Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor:: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993), Abstract;