BML-241 is a sphingosine-1-phosphate receptor antagonist. It blocks the S1P induced rapid Ca2+ increase in HeLa cells overexpressing S1P3 (EDG3) receptors (37% inhibition at 10 µM).
Product Details
| Alternative Name: | S1P Receptor Antagonist, 2(R,S)-Undecylthiazolidine-4(R)-carboxylic acid |
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| Formula: | C15H29NO2S |
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| MW: | 287.5 |
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| CAS: | 298186-80-8 |
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| Purity: | ≥98% |
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| Appearance: | White solid |
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| Solubility: | Soluble in DMSO (2mg/ml with warming), ethanol (1mg/ml with warming), or DMF (3mg/ml with warming). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Development of Novel EDG3 Antagonists Using a 3D Database Search and Their Structure−Activity Relationships: Y. Koide, et al. ; J. Med. Chem.
45, 4629 (2002),
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