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Sphingomyelinase inhibitor
BML-SL225-0001 1 mg 182.00 USD
BML-SL225-0005 5 mg 738.00 USD
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3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase.

Product Details

Purity:≥98% (TLC)
Identity:Determined by NMR.
Appearance:White to off-white solid.
Solubility:Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-SL225 structure
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BML-SL225 structure

Product Literature References

Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling: A.N. Kapustin, et al.; Commun. Biol. 4, 1241 (2021), Abstract;
Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition: Y. Chang, et al.; Int. J. Mol. Sci. 18, 2545 (2017), Abstract; Full Text

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