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Fumonisin B1

Ceramide synthase inhibitor
BML-SL220-0001 1 mg 111.00 USD
BML-SL220-0005 5 mg 495.00 USD
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Replaces Prod. #: ALX-350-017

A fungal metabolite produced by Fusarium moniliforme. Mycotoxin. Inhibits sphinganine N-acyl-transferase(ceramide synthase)(IC50=0.1µM). Inhibits de novo sphingolipid biosynthesis (IC50=0.7µM for sphingomyelin labeling by [3H]sphinganine, cultured cerebellar neurons). Inhibits growth of axons in cultured hippocampal neurons by blocking glycosphingolipid synthesis. Induces DNA damage in the liver and cancer. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.

Product Details

MI:14: 4289
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (25mg/ml).
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis: P. Tripathi, et al.; J. Lipid Res. 62, 100021 (2020), Abstract; Full Text
Necroptosis in primate luteolysis: a role for ceramide: K. Bagnjuk, et al.; Cell Death Dis. 5, 67 (2019), Application(s): Inhibition of Endogenous Ceramide Generation, Abstract; Full Text
Accumulation of long-chain bases in yeast promotes their conversion to long-chain base vinyl ether: F. Martínez-Montañés, et al.; J. Lipid Res. 57, 2040 (2016), Application(s): Yeast strains and growth conditions, Abstract; Full Text
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway: J. Coward, et al.; Autophagy 5, 184 (2009), Abstract;
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology 232, 163 (2007), Abstract;
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci. 61, 6 (2001), Review, Abstract;
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis 21, 1537 (2000), Abstract;
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS 93, 3461 (1996), Abstract;
Fumonisins: fungal toxins that shed light on sphingolipid function: A.H. Merrill, et al.; Trends Cell Biol. 6, 218 (1996), Abstract;
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon 31, 345 (1993), Abstract;
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem. 268, 27299 (1993), Abstract; Full Text
Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons: R. Harel & A.H. Futerman; J. Biol. Chem. 268, 14476 (1993), Abstract;
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem. 266, 14486 (1991), Abstract; Full Text

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