Replaces Prod. #: ALX-350-017
- Highly pure sphingosine n-acyl transferase inhibitor
- Used in a variety of reseach fields including cancer, food science, and neuroscience
Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium moniliforme. FB1 inhibits sphingosine N-acyl-transferase (ceramide synthase)(IC50 = 0.1µM) and de novo sphingolipid biosynthesis (IC50=0.7µM for sphingomyelin labeling by [3H]sphinganine, cultured cerebellar neurons). FB1 inhibits growth of axons in cultured hippocampal neurons by blocking glycosphingolipid synthesis. In CV-1 cells, FB1 induces DNA damage (5µM) and apoptosis (25µM). FB1 also activates Akt (PKB), which leads to increased survival, inhibition of GSK-3β activity, and post-translational stabilization of cyclin D1.
Product Details
| Alternative Name: | FB1 |
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| Formula: | C34H59NO15 |
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| MW: | 721.8 |
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| Source: | Isolated from Fusarium moniliforme. |
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| CAS: | 116355-83-0 |
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| MI: | 14: 4289 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Identity: | Identity determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Palmitoylation of acetylated tubulin and association with ceramide-rich platforms is critical for ciliogenesis: P. Tripathi, et al.; J. Lipid Res.
62, 100021 (2020),
Abstract;
Full Text
Necroptosis in primate luteolysis: a role for ceramide: K. Bagnjuk, et al.; Cell Death Dis.
5, 67 (2019),
Application(s): Inhibition of Endogenous Ceramide Generation,
Abstract;
Full Text
Accumulation of long-chain bases in yeast promotes their conversion to long-chain base vinyl ether: F. Martínez-Montañés, et al.; J. Lipid Res.
57, 2040 (2016),
Application(s): Yeast strains and growth conditions,
Abstract;
Full Text
Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res.
54, 87 (2015),
Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis,
Full Text
Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway: J. Coward, et al.; Autophagy
5, 184 (2009),
Abstract;
Fumonisin B(1): oxidative status and DNA damage in rats: A.M. Domijan, et al.; Toxicology
232, 163 (2007),
Abstract;
Implications of apoptosis for toxicity, carcinogenicity, and risk assessment: fumonisin B(1) as an example: Y.P. Dragan, et al.; Toxicol. Sci.
61, 6 (2001), Review,
Abstract;
A potential mechanism for fumonisin B(1)-mediated hepatocarcinogenesis: cyclin D1 stabilization associated with activation of Akt and inhibition of GSK-3beta activity: D. Ramljak, et al.; Carcinogenesis
21, 1537 (2000),
Abstract;
Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells: H. Wang, et al.; PNAS
93, 3461 (1996),
Abstract;
Fumonisins: fungal toxins that shed light on sphingolipid function: A.H. Merrill, et al.; Trends Cell Biol.
6, 218 (1996),
Abstract;
Biological activities of fumonisins, mycotoxins from Fusarium moniliforme, in jimsonweed (Datura stramonium L.) and mammalian cell cultures: H.K. Abbas, et al.; Toxicon
31, 345 (1993),
Abstract;
Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ: A.H. Merrill Jr., et al.; J. Biol. Chem.
268, 27299 (1993),
Abstract;
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Inhibition of sphingolipid synthesis affects axonal outgrowth in cultured hippocampal neurons: R. Harel & A.H. Futerman; J. Biol. Chem.
268, 14476 (1993),
Abstract;
Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme: E. Wang, et al.; J. Biol. Chem.
266, 14486 (1991),
Abstract;
Full Text
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