Sphingosylphosphorylcholine induces release of Ca2+ from intracellular stores via an IP3 independent pathway in permeabilized pancreatic acinar cells. It is an extremely potent mitogen in numerous cell types and induces neurite outgrowth in mouse neuroblastoma cells. It rapidly activates transcription factor AP-14 and transiently activates MAP kinase.
Product Details
| Formula: | C23H49N2O5P |
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| MW: | 464.6 |
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| CAS: | 82970-80-7 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Waxy solid. |
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| Solubility: | Soluble in water (>50 mg/ml) or ethanol (>50 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A novel trigger for cholesterol-dependent smooth muscle contraction mediated by the sphingosylphosphorylcholine-Rho-kinase pathway in the rat basilar artery: a mechanistic role for lipid rafts: S. Shirao, et al.; J. Cereb. Blood Flow Metab.
35, 835 (2015),
Application(s): Injection,
Abstract;
Sphingosylphosphocholine, a signaling molecule which accumulates in Niemann-Pick disease type A, stimulates DNA-binding activity of the transcription activator protein AP-1: A. Berger, et al.; Proc. Natl. Acad. Sci. U. S. A.
92, 5885 (1995),
Abstract;
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Sphingosylphosphorylcholine activation of mitogen-activated protein kinase in Swiss 3T3 cells requires protein kinase C and a pertussis toxin-sensitive G protein: T. Seufferlein, et al.; J. Biol. Chem.
270, 24334 (1995),
Abstract;
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Metabolism and neurite promoting effect of exogenous sphingosylphosphocholine in cultured murine neuroblastoma cells: E. Sugiyama, et al.; J. Biochem.
113, 467 (1993),
Abstract;
Signaling pathways for sphingosylphosphorylcholine-mediated mitogenesis in Swiss 3T3 fibroblasts: N. N. Desai, et al.; J. Cell. Biol.
121, 1385 (1993),
Abstract;
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Sphingosine metabolism induces Ca2+ oscillations in rat pancreatic acinar cells: D.I. Yule, et al.; J. Biol. Chem.
268, 12353 (1993),
Abstract;
