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C16 Ceramide

Endogenous ceramide
 
BML-SL115-0005 5 mg 71.00 USD
 
BML-SL115-0025 25 mg 301.00 USD
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Replaces Prod. #: ALX-306-025

An abundant molecular species of endogenous ceramide. It induces phosphorylation of epidermal growth factor receptor on Thr669 in A-431 cells by stimulation of ceramide-activated protein kinase and activates NF-κB at concentrations as low as 50 nM. Activates PKCζ.

Product Specification

Alternative Name:N-Palmitoyl-D-erythro-sphingosine, N-Hexadecanoyl-D-erythro-sphingosine, N-Palmitoyl ceramide
 
Formula:C34H67NO3
 
MW:537.9
 
CAS:24696-26-2
 
Purity:≥98% (TLC)
 
Appearance:Solid.
 
Solubility:Soluble in 100% ethanol (5mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Cholesterol-pyrene as a probe for cholesterol distribution on ordered and disordered membranes: Determination of spectral wavelengths: C. Almeida, et al.; PLoS One 13, e0201373 (2018), Abstract; Full Text
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid: G. Muller, et al.; EMBO J. 14, 1961 (1995), Abstract;
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase: J. Lozano, et al.; J. Biol. Chem. 269, 19200 (1994), Abstract;
Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha: S. Mathias, et al.; Proc. Natl. Acad. Sci. USA 88, 10009 (1991), Abstract;

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