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C6 Ceramide

Cell-permeable ceramide analog



BML-SL110-0005	5 mg	82.00 USD

BML-SL110-0025	25 mg	367.00 USD
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Replaces Prod. #: ALX-303-003

A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G₀/G₁ transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.

Product Details

Alternative Name:	N-Hexanoyl-D-erythro-sphingosine

Formula:	C₂₄H₄₇NO₃

MW:	397.7

CAS:	124753-97-5

Purity:	≥98% (TLC)

Appearance:	White waxy solid.

Solubility:	Soluble in 100% ethanol (>25mg/ml) and DMSO (>50mg/ml).

Shipping:	Ambient Temperature

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways: T. Blom, et al.; Nat. Chem. Biol. 11, 799 (2015), Abstract;

Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction: A. Molano, et al.; PLoS One 7, e47650 (2012), Abstract; Full Text

Role for ceramide in cell cycle arrest: S. Jayadev, et al.; J. Biol. Chem. 270, 2047 (1995), Abstract;

Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence: M.E. Venable, et al.; J. Biol. Chem. 269, 26040 (1994), Abstract;

Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; Proc. Natl. Acad. Sci. USA 91, 73 (1994), Abstract;

Ceramide activates heterotrimeric protein phosphatase 2A: R.T. Dobrowsky, et al.; J. Biol. Chem. 268, 15523 (1993), Abstract;

Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells: M.A. Raines, et al.; J. Biol. Chem. 268, 14572 (1993), Abstract;

Ceramide stimulates a cytosolic protein phosphatase: R.T. Dobrowsky & Y.A. Hannun; J. Biol. Chem. 267, 5048 (1992), Abstract;