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C6 Ceramide

Cell-permeable ceramide analog
 
BML-SL110-0005 5 mg 67.00 USD
 
BML-SL110-0025 25 mg 300.00 USD
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Replaces Prod. #: ALX-303-003

A biologically active, cell-permeable, but nonphysiologic ceramide analog. It activates protein phosphatase 2A and MAP kinase (MAPK/ERK), suppresses insulin-induced tyrosine phosphorylation and inhibits glycoprotein traffic by the secretory pathway. It inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. It induces an arrest at the G0/G1 transition of the cell cycle (10μM) and causes apoptosis (15μM or greater) in Molt-4 leukemia cells.

Product Specification

Alternative Name:N-Hexanoyl-D-erythro-sphingosine
 
Formula:C24H47NO3
 
MW:397.7
 
CAS:124753-97-5
 
Purity:≥98% (TLC)
 
Appearance:White waxy solid.
 
Solubility:Soluble in 100% ethanol (>25mg/ml) and DMSO (>50mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

LAPTM4B facilitates late endosomal ceramide export to control cell death pathways: T. Blom, et al.; Nat. Chem. Biol. 11, 799 (2015), Abstract;
Age-dependent changes in the sphingolipid composition of mouse CD4+ T cell membranes and immune synapses implicate glucosylceramides in age-related T cell dysfunction: A. Molano, et al.; PLoS One 7, e47650 (2012), Abstract; Full Text
Role for ceramide in cell cycle arrest: S. Jayadev, et al.; J. Biol. Chem. 270, 2047 (1995), Abstract;
Identification of a defect in the phospholipase D/diacylglycerol pathway in cellular senescence: M.E. Venable, et al.; J. Biol. Chem. 269, 26040 (1994), Abstract;
Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway: W.D. Jarvis, et al.; Proc. Natl. Acad. Sci. USA 91, 73 (1994), Abstract;
Ceramide activates heterotrimeric protein phosphatase 2A: R.T. Dobrowsky, et al.; J. Biol. Chem. 268, 15523 (1993), Abstract;
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells: M.A. Raines, et al.; J. Biol. Chem. 268, 14572 (1993), Abstract;
Ceramide stimulates a cytosolic protein phosphatase: R.T. Dobrowsky & Y.A. Hannun; J. Biol. Chem. 267, 5048 (1992), Abstract;

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