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Abl1 (human), (recombinant) (His-tag)

BML-SE562-0005 5 µg 297.00 USD
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Product Details

Alternative Name:Abelson murine leukemia viral oncogene homolog 1
Sequence:Human recombinant Abl1 (aa 27-1130) with N-terminal histidine tag.
Source:Produced in insect cells. Produced in a baculovirus expression system.
UniProt ID:P00519
Formulation:Liquid. In 50mM sodium phosphate, pH 7.0, containing 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
Purity:≥70% (SDS-PAGE)
Application Notes:Useful tool to study enzyme regulation and kinetics, phosphorylate target substrates, screen for inhibitors.
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles.
Scientific Background:The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in cell differentiation, cell division, cell adhesion, and stress responses. The c-Abl protein is inhibited by its SH3 domain, and deletion of this domain turns ABL1 into an oncogene. A chromosomal translocation results in the head-to-tail fusion of the BCR and ABL1 genes. This translocation is present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of Abl1 is regulated by CDC2-mediated phosphorylation.
Regulatory Status:RUO - Research Use Only

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