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RAP (human), (recombinant)

BML-SE552-0100 100 µg 422.00 USD
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Product Details

Alternative Name:LDL receptor associated protein, LRPAP1, LDL receptor-related protein-associated protein 1
MW:~39kDa (SDS-PAGE)
Source:Produced in E. coli.
UniProt ID:P30533
Formulation:Liquid. In 0.0067M Phosphate, pH 7.4 containing 0.15M sodium chloride.
Purity:≥90% (SDS-PAGE)
Application Notes:Useful tool for binding studies, and testing in vivo and in cell culture.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C.
Scientific Background:RAP functions in ER maturation of lipoprotein receptor family members by acting as an antagonist. It blocks binding of PCSK9 to lipoprotein receptors and of all known ligands (including MMP-9 and apoE) to lipoprotein receptor-related protein 1 (LRP-1). Modulates amyloid deposition in mouse models of Alzheimer’s disease. Reduces endocytosis of prion protein (PrPc) by neuronal cells.
Regulatory Status:RUO - Research Use Only

Product Literature References

Cell-based artificial APC resistant to lentiviral transduction for efficient generation of CAR-T cells from various cell sources: A. Schmidts, et al.; J. Immunother. Cancer 8, e000990 (2020), Abstract; Full Text
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response: L. Hu, et al.; Redox Biol. 26, 101268 (2019), Application(s): Treatment of human monocyte-derived macrophages (HMDM) cell cultures, Abstract; Full Text
Lactoferrin induces tropoelastin expression by activating the lipoprotein receptor-related protein 1-mediated phosphatidylinositol 3-kinase/Akt pathway in human dermal fibroblasts: M. Ryu, et al.; Cell Biol. Int. 41, 1325 (2017), Application(s): Treatment of primary normal human dermal fibroblasts in cell culture, Abstract;

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