| Alternative Name: | Phosphodiesterase 10A |
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| MW: | ~87kDa |
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| Source: | Produced in E. coli. Recombinant human phosphodiesterase 10A (aa 14-779). |
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| UniProt ID: | Q9Y233 |
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| Formulation: | Liquid. In 20mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride and 2mM DTT. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Application Notes: | Useful tool to study enzyme regulation and kinetics, screen for inhibitors or activators of PDE10A. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | After rapid initial defrost, aliquot product into individual tubes and refreeze the remaining, unused enzyme quickly by snap-freezing in a dry/ice ethanol bath or liquid nitrogen, if possible. |
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| Scientific Background: | This enzyme can hydrolyze both cAMP and cGMP, but has a higher affinity for cAMP. In the brain it is present in neuronal cell bodies and neuropil of the striatum, in striatonigral and striatopallidal white matter tracks, and in the substantia nigra and globus pallidus. Outside the brain it is found in the testis, epididymal sperm, and enteric ganglia. It is under investigation as a drug target for schizophrenia and diabetes. |
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| Regulatory Status: | RUO - Research Use Only |
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