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HDAC3 (human), (recombinant) (His-tag)

Highly active
 
BML-SE507-0050 50 µg 467.00 USD
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Product Specification

Alternative Name:Histone deacetylase 3
 
MW:49 kDa
 
Source:Produced in insect cells. Produced in a baculovirus expression system.
 
UniProt ID:O15379
 
Gene/Protein Identifier:NM_003883 (RefSeq)
 
Formulation:Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
 
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
 
Specific Activity:≥0.7 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:HDAC3, although a class I HDAC and has been assigned to its own phylogenetic subclass and its caspase-dependent cleavage and relocation to the cytoplasm may be critical to the progression of apoptosis, implying an important role in pathways affecting heart disease.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Mitotic Activation of a Novel Histone Deacetylase 3-Linker Histone H1.3 Complex by Protein Kinase CK2: H. Patil, et al.; J. Biol. Chem. 291, 3158 (2016), Application(s): Pull down assay, Abstract; Full Text
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment: J.T. Isaacs, et al.; Cancer Res. 73, 1386 (2012), Abstract;
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis: M.M. Mihaylova, et al.; Cell 145, 607 (2011), Abstract; Full Text

Related Products

FLUOR DE LYS®-SIRT1 deacetylase substrate 

≥95% (HPLC) | Print as PDF
 
BML-KI177-0005 0.5 µmol 216.00 USD
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