Product Details
| Alternative Name: | Histone deacetylase 2 |
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| MW: | 55 kDa |
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| Source: | Produced in insect cells. Produced in a baculovirus expression system. |
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| UniProt ID: | Q92769 |
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| Formulation: | Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Purity Detail: | Purified by multi-step chromatography. |
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| Specific Activity: | ≥10 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS®-SIRT1 substrate (p53 K(Ac)-382 fluorogenic substrate, Prod. No. BML-KI177). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | HDAC2, like the highly homologous HDAC1, is a class I HDAC first identified as a human homolog of the yeast histone deacetylase Rpd3. HDAC2 found, along with HDAC1 in the Sin3, NuRD. In contrast to class II HDACs, which repress cardiac hypertrophy, HDAC2 activity is required for the cardiac hypertrophic response. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells: M.A. Fischer, et al.; J. Adv. Res. (2023),
Abstract;
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