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Proteinase 3 (human neutrophils)

Highly active and high purity serine protease.
BML-SE498-0025 25 µg Inquire for pricing
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Product Details

Alternative Name:PR3, Myeloblastin, Wegener's autoantigen
Source:Isolated from human sputum neutrophils.
UniProt ID:P24158
Purity:≥95% (SDS-PAGE). Contains no elastase or cathepsin G.
Specific Activity:≥50 U/mg, where one unit hydrolyzes 1μmole of 250μM Boc-Ala-Ala-Nva-SBzl per minute at 25°C in 100mM MOPS pH 7.5, 500mM NaCl, 10% DMSO, 100μM DTNB.
Application Notes:Useful to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
Reconstitution:Reconstitute in 25 µL deionized water.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Use/Stability:Although this is in highly purified form, and the source material tested negative for syphilis, HIV-1/HIV-2, Hepatitis B, Hepatitis C, and HTLV-1, handle this product with all due precautions.
Scientific Background:Proteinase 3 is a neutral serine protease located in neutrophil azurophil granules. It is closely related to neutrophil elastase and can cleave elastin. PR3 is involved in diseases such as Wegener’s granulomatosis, emphysema, vasculitis, and other inflammatory diseases.
Regulatory Status:RUO - Research Use Only

Product Literature References

Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis: K.J. Chen, et al.; Phytomedicine 101, 154092 (2022), Abstract;
Amblyomma americanum serpin 27 (AAS27) is a tick salivary anti-inflammatory protein secreted into the host during feeding: L. Tirloni, et al.; PLoS Negl. Trop. Dis. 13, e0007660 (2019), Abstract; Full Text
Neutrophil proteinase 3 (PR3) acts on protease-activated receptor-2 (PAR-2) to enhance vascular endothelial cell barrier function: C.J. Kuckleburg, et al.; Arterioscler. Thromb. Vasc. Biol. 33, 275 (2013), Application(s): Cell Culture, Abstract; Full Text
Proteinase 3 reactive T cells in patients with granulomatosis with polyangiitis: S. Scollard, et al.; La Presse Médicale 42, 716 (2013), (Poster), Application(s): Cell Culture, Full Text

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