| Alternative Name: | AMP-activated kinase |
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| Source: | Produced in insect cells. Full length active AMPK composed of subunits α1, β1 and γ1. Produced in a baculovirus expression system. |
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| UniProt ID: | Q13131 (α1 subunit), Q9Y478 (β1 subunit), P54619 (γ1 subunit) |
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| Application Notes: | Useful tool for kinetic and functional studies, drug screening. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that is conserved in all eukaryotic cells. AMPK comprises three subunits; the α subunit is catalytic, the β subunit contains a glycogen-sensing domain, and the γ contains two regulatory sites that bind the activating and inhibitory nucleotides AMP and ATP. Hormones and cytokines such as insulin, leptin, and adiponectin interact with the system, and it appears to play a key role in maintaining energy balance at the whole body level. The AMPK system is the target for the antidiabetic drug metformin. |
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| Regulatory Status: | RUO - Research Use Only |
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