| Alternative Name: | Fibroblast activation protein α, Seprase, Surface expressed protease, APCE, Antiplasmin cleaving enzyme |
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| MW: | 86 kDa |
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| Source: | Produced in a baculovirus expression system. Active recombinant human FAP (aa 29-760), representing a naturally-occurring cleaved (soluble) form fused at the C-terminus to a His-tag. |
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| UniProt ID: | Q12884 |
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| Formulation: | Liquid. In 40mM TRIS-HCl, pH 8.0, containing 110mM NaCl, 2.2mM KCl, 200mM imidazole, 20% glycerol and 3mM DTT. |
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| Application Notes: | Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | FAP is a homodimeric serine prolyl peptidase that digests gelatin, collagen, and α2-antiplasmin. Due to its implication in cancer and blood disorders, it is a target for drug discovery. In addition, because this enzyme is related to DPPIV, it is useful for specificity screening of DPPIV inhibitors. |
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| Regulatory Status: | RUO - Research Use Only |
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