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Thrombin (human plasma), (purified)

 
BML-SE363-1000 1000 U 427.00 USD
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Product Specification

MW:37 kDa
 
Source:The human Thrombin was activated from homogeneous human prothrombin by activation with Factor Xa, Factor Va, and phospholipid. These activation enzymes were removed after activation. Complete activation was observed on SDS-PAGE. The above protein was purified from Human plasma units that test negative for antibodies to HBc, HCV, HIV 1/2, HTLV-I/II, and non-reactive for HBsAg, HIV-1 RNA, HCV RNA, HBV DNA and Syphilis by FDA approved tests. Donors are screened for CJD.
 
UniProt ID:P00734
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Scientific Background:Thrombin (factor IIa) is a serine endopeptidase comprising a light and a heavy chain, the latter being the catalytic subunit. Thrombin is a necessary component of the clotting cascade, and is important in cardiovascular research and drug development, and may play a role in Alzheimer’s disease as well.
 
Regulatory Status:RUO - Research Use Only
 

Product Literature References

Release of platelet-derived sphingosine-1-phosphate involves multidrug resistance protein 4 (MRP4/ABCC4) and is inhibited by statins: K. Vogt, et al.; Thromb. Haemost. 118, 132 (2018), Abstract;
Multiple modes of capillary electrophoresis applied in peptide nucleic acid related study: X. Wang, et al.; J. Chromatogr. A. 1501, 161 (2017), Abstract;

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