Replaces Prod. #: ADI-PPK-425
Product Details
| Alternative Name: | Glycogen synthase kinase 3β |
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| MW: | 73 kDa |
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| Source: | Produced in insect cells. Full length human glycogen synthase kinase-3ß is fused at the N-terminus to a GST-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | P49841 |
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| Application Notes: | Useful for Useful for kinetic and functional studies, phosphorylation of target substrates, drug screening. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | GSK-3β, a serine/threonine kinase, is involved in many cell functions, including, insulin, growth factor and nutrient signaling, cell division, apoptosis, modulation of transcription factors AP-1 and CREB, and specification of cell fate. Phosphorylation of GSK-3β on serine 9 results in its inactivation. GSK-3β has also been shown to phosphorylate tau, the major component of neurofibrillary lesions of Alzheimer’s disease. |
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| Technical Info/Product Notes: | Replacement for ADI-PPK-425 |
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| Regulatory Status: | RUO - Research Use Only |
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