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United States 

Calmodulin (human), (recombinant)

Calcium-binding protein produced in E.coli
BML-SE325-0001 1 mg 285.00 USD
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Replaces Prod. #: ALX-200-005

Product Details

Alternative Name:CaM, Phosphodiesterase 3':5'-cyclic nucleotide activator
Sequence:Sequence identical to Genbank accession M27319.1.
MW:16.8 kDa
Source:Produced in E. coli.
MI:14: 1719
UniProt ID:P62158
Formulation:Lyophilized. Salt-free.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Biological Activity:Elicits Ca2+-dependent activation of calcineurin (Ca2+/calmodulin-dependent Ser/Thr protein phosphatase 2B, PP-2B) with the same potency and to the same maximum extent as purified native calmodulin.
Application Notes:Calmodulin can be used to activate calmodulin-dependent phosphodiesterase, calcineurin, CaM kinases, etc.
Reconstitution:Reconstitute in water or an appropriate buffer.
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Regulatory Status:RUO - Research Use Only
Calmodulin (human), (recombinant) activation
Human recombinant calmodulin (Prod. No. BML-SE325) activation of human calcineurin is essentially identical to that of purified bovine brain calmodulin (native, bovine). Initial rates of calcineurin phosphatase activity were determined as a function of calmodulin concentration with the Calcineurin Colorimetric Drug Discovery Kit (Prod. No. BML-AK804). (Note that the human and bovine calmodulin amino acid sequences are 100% identical.)
Calmodulin (human), (recombinant) SDS-PAGE
SDS-PAGE Analysis: Lane 1: MW Marker; Lane 2: 1.0 µg of purified human recombinant calmodulin protein (Prod. No. BML-SE325).
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Calmodulin (human), (recombinant) activation Calmodulin (human), (recombinant) SDS-PAGE

Product Literature References

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly: T. Niu, et al.; Nat. Commun. 12, 5862 (2021), Abstract;
Paxillin-Mediated Recruitment of Calcineurin to the Contractile Ring Is Required for the Correct Progression of Cytokinesis in Fission Yeast: R. Martin-Garcia, et al.; Cell Rep. 25, 772 (2018), Abstract;
A model for regulation by SynGAP-α1 of binding of synaptic proteins to PDZ-domain 'Slots' in the postsynaptic density: W.G. Walkup, et al.; Elife 5, e22495 (2016), Application(s): Measurement of affinity of CaM for r-synGAP-a1 by SPR, Abstract; Full Text
The phosphatase calcineurin regulates pathological TDP-43 phosphorylation: N.F. Liachko, et al.; Acta Neuropathol. 4, 545 (2016), Abstract;
Dissecting cooperative communications in a protein with a high-throughput single-molecule scalpel: Z. Yu, et al.; Chemphyschem. 16, 223 (2015), Abstract;

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