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Tau-441 (2N4R variant) (human), (recombinant)

BML-SE321-0100 100 µg 794.00 USD
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Product Details

Source:Produced in E. coli.
UniProt ID:P10636
Formulation:Lyophilized from 50mM MES, pH 6.8, 100mM sodium chloride and 0.5mM EGTA.
Purity:≥90% (SDS-PAGE)
Application Notes:This protein is purified without any acid treatment and is suitable for promoting microtubule assembly, and for hyperphosphorylation-induced self-assembly into filaments.
Reconstitution:Reconstitute with distilled water to a concentration of 1mg/ml.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles.
Scientific Background:The tau proteins are major neuronal microtubule-associated proteins that function in the stabilization of microtubules and accumulate in various abnormal filaments including neurofibrillary tangles, neuropil threads and amyloid plaques in the pathology of Alzheimer's disease. Six tau isoforms are derived from alternative mRNA splice variants that originate from a single gene and result in mature proteins that vary in size from 352 to 441 amino acids (36.8 to 45.9 kDa). The six isoforms differ from one another in having three or four microtubule binding repeats (R) and two, one or zero amino terminal inserts (N). While the fetal brain contains a single isoform of tau (TAU-352), the adult brain has several isoforms.
Regulatory Status:RUO - Research Use Only

Product Literature References

A Quantitative LC-MS/MS Method for Distinguishing the Tau Protein Forms Phosphorylated and Nonphosphorylated at Serine-396: A.M. Jacobsen, et al.; J. Am. Soc. Mass Spectrom. 34, 441 (2023), Abstract;
Real-Time Tau Protein Detection by Sandwich-Based Piezoelectric Biosensing: Exploring Tubulin as a Mass Enhancer: D. Li, et al.; Sensors (Basel) 18, 946 (2018), Abstract; Full Text
Gold nanoparticle-based immuno-PCR for detection of tau protein in cerebrospinal fluid: L. Stegurova, et al.; J. Immunol. Methods 406, 137 (2014), Abstract;
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism: T. Dange, et al.; J. Biol. Chem. 286, 42830 (2011), Abstract; Full Text

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