Product Details
| Alternative Name: | GCN5L2, Histone acetyltransferase GCN5 |
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| MW: | 19.4 kDa |
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| Source: | Produced in E. coli. Catalytic domain (aa 497-663) of human hGCN5L. |
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| UniProt ID: | Q92830 |
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| Formulation: | Liquid. In 20mM sodium citrate, pH 6.0, containing 0.25M NaCl, 1mg/ml BSA and 10% glycerol. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Purity Detail: | Purified by multi-step chromatography. |
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| Specific Activity: | ≥200 pmol/min./µg assayed as production of CoA-SH from AcCoA in the presence of a peptide comprising human histone H3 residues 5-23. CoA-SH is determined with a fluorogenic, thiol-reactive maleimide (CPM). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | hGCN5L is the catalytic histone acetyltransferase (HAT) subunit of the transcriptional coactivator complexes STAGA and TFTC. |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE Analysis: Lane 1: MWM; Lane 2: 1.0 ug of purified GCN5 protein, with 1 mg/ml BSA.
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Product Literature References
Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosom: A. Furukawa, et al.; iScience
25, 103937 (2022),
Abstract;
The DNA intercalators ethidium bromide and propidium iodide also bind to core histones: A. Banerjee, et al.; FEBS Open Bio
4, 251 (2014),
Abstract;
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