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SIRT2 (human), (recombinant) (His-tag)

BML-SE251-0500 500 U 531.00 USD
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Product Details

Alternative Name:Sirtuin 2
MW:43 kDa
Source:Produced in E. coli. Contains a N-terminal His-tag.
UniProt ID:Q8IXJ6
Formulation:Liquid. In 25mM TRIS, pH 7.5, containing 100mM NaCl, 5mM DTT and 10% glycerol.
Purity Detail:Purified by multi-step chromatography.
Specific Activity:One unit will deacetylate 1pmol/min of FLUOR DE LYS®-SIRT2 substrate (Prod. No. BML-KI179).
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Due to their roles in gene silencing, aging, and oxidative stress responses, it is believed that sirtuins (NAD-dependent lysine deacetylases) play a crucial role in cell metabolism. Human SIRT2 is a class I sirtuin, although not as closely related to Sir2 and human SIRT1. Its catalytic core has the same basic two-domain architecture and central groove as other sirtuins and an interaction with the homeobox transcription factor HOXA10.
Regulatory Status:RUO - Research Use Only

Product Literature References

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site: P. Mellini, et al.; J. Med. Chem. 62, 5844 (2019), Abstract;
Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors: G. Eren, et al.; J. Mol. Graph. Model. 10, 1313 (2019), Abstract;
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors: E. Therrien, et al.; Bioorg. Med. Chem. Lett. 25, 2514 (2015), Abstract;
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase: V. Nin, et al.; J. Biol. Chem. 287, 23489 (2012), Abstract; Full Text
A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK): B.M. Hirsch, et al.; Bioorg. Med. Chem. Lett. 21, 4753 (2011), Abstract; Full Text

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