Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

SIRT2 (human), (recombinant) (His-tag)

BML-SE251-0500 500 U 436.00 USD
Do you need bulk/larger quantities?

Product Specification

Alternative Name:Sirtuin 2
MW:43 kDa
Source:Produced in E. coli. Contains a N-terminal His-tag.
UniProt ID:Q8IXJ6
Formulation:Liquid. In 25mM TRIS, pH 7.5, containing 100mM NaCl, 5mM DTT and 10% glycerol.
Purity Detail:Purified by multi-step chromatography.
Specific Activity:One unit will deacetylate 1pmol/min of FLUOR DE LYS®-SIRT2 substrate (Prod. No. BML-KI179).
Shipping:Shipped on Dry Ice
Long Term Storage:-80°C
Scientific Background:Due to their roles in gene silencing, aging, and oxidative stress responses, the sirtuins (NAD. Like Sir2, human SIRT2 is a class I sirtuin, although not as closely related to Sir2 and human SIRT1 and its catalytic core has the same basic two-domain architecture and central groove as other sirtuinsand an interaction with the homeobox transcription factor HOXA10.
Regulatory Status:RUO - Research Use Only

Product Literature References

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site: P. Mellini, et al.; J. Med. Chem. 62, 5844 (2019), Abstract;
Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors: G. Eren, et al.; J. Mol. Graph. Model. 10, 1313 (2019), Abstract;
Discovery of bicyclic pyrazoles as class III histone deacetylase SIRT1 and SIRT2 inhibitors: E. Therrien, et al.; Bioorg. Med. Chem. Lett. 25, 2514 (2015), Abstract;
Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase: V. Nin, et al.; J. Biol. Chem. 287, 23489 (2012), Abstract; Full Text
A mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK): B.M. Hirsch, et al.; Bioorg. Med. Chem. Lett. 21, 4753 (2011), Abstract; Full Text

Related Literature

Stem Cells
Stem Cells
Download as PDF

Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2020 Enzo Life Sciences, Inc.,