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Granzyme B (human), (recombinant)

BML-SE238-5000 5000 U 531.00 USD
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Product Details

MW:25.4 kDa
Source:Produced in yeast. Recombinant human granzyme B (aa 21-247).
UniProt ID:P10144
Concentration:100 U/µl
Formulation:Liquid. In 50mM TRIS, pH 7.4, 100mM NaCl, 10% glycerol.
Purity Detail:Partially purified by single-step affinity chromatography and gel filtration.
Biological Activity:A serine protease with caspase-like substrate specificity.
Specific Activity:One unit hydrolyzes 1 pmol/min of Ac-IEPD-pNA (200 µM, Prod. No. BML-P133) at 30°C.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Granzyme B is a component of the cytolytic granules of cytotoxic T lymphocytes and natural killer cells.
Regulatory Status:RUO - Research Use Only

Product Literature References

Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells: A.L. Pourzia, et al.; Cell Death Dis. 14, 267 (2023), Abstract;
Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells: S.R. Woo, et al.; Biochem. Biophys. Res. Commun. 503, 1812 (2018), Abstract;
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Enhanced expression of PD L1 in cervical intraepithelial neoplasia and cervical cancers: L. Mezache, et al.; Mod. Pathol. 28, 1594 (2015), Application(s): Immunohistochemistry, Abstract;
Measurement of Cellular Immunity to Influenza Vaccination in Rheumatoid Arthritis; Comparison of Three Assays: N. Madar-Balakirski, et al.; J. Vaccines Vaccin. 6, 1000278 (2015), Application(s): Activity Assay, Full Text
Approaches to design non-covalent inhibitors for human granzyme B (hGrB): M. Kim, et al.; Org. Biomol. Chem. 12, 8952 (2014), Abstract;
Proteinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis: W.F. Pendergraft, et al.; Kidney Int. 65, 75 (2004), Abstract;

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