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Cathepsin D (human liver), (purified)

BML-SE199-0025 25 µg 286.00 USD
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Product Details

Source:Isolated from human liver.
UniProt ID:P07339
Formulation:Lyophilized with phosphate buffer.
Purity:≥95% (SDS-PAGE)
Application Notes:Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture.
Reconstitution:Reconstitute just before first use with original volume of water.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
Scientific Background:Cathepsin D is a lysosomal protease that can also be secreted from the cell and is involved in protein degradation, apoptosis, and cancer.
Regulatory Status:RUO - Research Use Only

Product Literature References

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40: C.N. Suire, et al.; Alzheimers Res. Ther. 12, 80 (2020), Abstract; Full Text
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy: A.P. Kiely, et al.; Neuropathol. Appl. Neurobiol. 45, 347 (2019), Abstract;
Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium: F.H. Al-Awadhi, et al.; Bioorg. Med. Chem. 24, 3276 (2016), Application(s): In vitro protease inhibition assays, Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem. 21, 2975 (2013), Abstract;

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