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MMP-7 (catalytic domain) (human), (recombinant)

BML-SE181-0010 10 µg 506.00 USD
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Product Details

Alternative Name:Matrix metalloproteinase 7, Matrilysin, Pump
MW:20.4 kDa
Source:Produced in E. coli. Active Matrix Metalloproteinase-7 (MMP-7, matrilysin, pump) catalytic domain from human cDNA. The enzyme consists of the catalytic domain of human MMP-7 (Tyr95-Lys267, NM_002423) with a C-terminal purification tag.
UniProt ID:P09237
Formulation:Liquid. In 50 mM Tris-HCl pH 7.5, 5 mM CaCl2, 300 mM NaCl, 20 µM ZnCl2, 0.5% Brij-35, and 30% glycerol.
Purity:≥95% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Activity:Preincubation of MMP-7 catalytic domain at 19nM with the broad-spectrum inhibitor GM6001 (Prod. No. BML-EI300) at 100nM for 1 hour completely inhibits enzymatic activity.
Specific Activity:≥200 pmol/min/µg at 37°C using the colorimetric thiopeptolide Ac-Pro-Leu-Gly-S-Leu-Leu-GlyOEt (100 µM; Prod. No. BML-P125) as substrate.
Application Notes:Useful tool to study enzyme kinetics, cleave target substrates, and screen for inhibitors.
Shipping:Dry Ice
Long Term Storage:-80°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14: U. Eckhard, et al.; Data Brief 7, 299 (2016), Application(s): Quenched fluorescence protease activity assay, Abstract; Full Text
The Dendritic Cell Major Histocompatibility Complex II (MHC II) Peptidome Derives from a Variety of Processing Pathways and Includes Peptides with a Broad Spectrum of HLA-DM Sensitivity: C.C. Clement, et al.; J. Biol. Chem. 291, 5576 (2016), Abstract; Full Text
The in vitro resistance of IgG2 to proteolytic attack concurs with a comparative paucity of autoantibodies against peptide analogs of the IgG2 hinge: R.J. Brezski, et al.; Mabs 3, 558 (2011), Abstract; Full Text

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