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Caspase-4 (human), (recombinant)

BML-SE176-5000 5000 U 531.00 USD
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Product Details

Alternative Name:ICH-2, Protease TX, ICErel-II
MW:19 + 10 kDa
Source:Produced in E. coli.
UniProt ID:P49662
Formulation:Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1mM EDTA, 10% glycerol, 10mM DTT.
Purity:≥90% (SDS-PAGE)
Activity:100 U/µl
Specific Activity:One U=1 pmol/min at 30°C using Ac-LEHD-pNA (200 mM; Prod. No. ALX-260-081) as substrate.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Caspase-4 is localized primarily to the endoplasmic reticulum (ER) and is required for mediation of ER-stress induced apoptosis.
Regulatory Status:RUO - Research Use Only

Product Literature References

The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion: S. Wang, et al.; PLoS Pathog. 18, e1010415 (2022), Abstract;
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C: R. Mintzer, et al.; PLoS One 7, e30376 (2012), Abstract; Full Text
Water-soluble carbon nanotube-enzyme conjugates as functional biocatalytic formulations: P. Asuri, et al.; Biotechnol. Bioeng. 95, 804 (2006), Abstract;
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts: X. Yang, et al.; Am. J. Pathol. 167, 705 (2005), Abstract;
KIPase activity is a novel caspase-like activity associated with cell proliferation: C. Medina-Palazon, et al.; Eur. J. Biochem. 271, 2716 (2004), Abstract; Full Text
Printing chemical libraries on microarrays for fluid phase nanoliter reactions: D.N. Gosalia, et al.; Proc. Natl. Acad. Sci. U. S. A. 100, 8721 (2003), Abstract; Full Text