Product Details
| Alternative Name: | ICH-2, Protease TX, ICErel-II |
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| MW: | 19 + 10 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P49662 |
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| Formulation: | Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1mM EDTA, 10% glycerol, 10mM DTT. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Activity: | 100 U/µl |
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| Specific Activity: | One U=1 pmol/min at 30°C using Ac-LEHD-pNA (200 mM; Prod. No. ALX-260-081) as substrate. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Caspase-4 is localized primarily to the endoplasmic reticulum (ER) and is required for mediation of ER-stress induced apoptosis. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion: S. Wang, et al.; PLoS Pathog.
18, e1010415 (2022),
Abstract;
A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C: R. Mintzer, et al.; PLoS One
7, e30376 (2012),
Abstract;
Full Text
Water-soluble carbon nanotube-enzyme conjugates as functional biocatalytic formulations: P. Asuri, et al.; Biotechnol. Bioeng.
95, 804 (2006),
Abstract;
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts: X. Yang, et al.; Am. J. Pathol.
167, 705 (2005),
Abstract;
KIPase activity is a novel caspase-like activity associated with cell proliferation: C. Medina-Palazon, et al.; Eur. J. Biochem.
271, 2716 (2004),
Abstract;
Full Text
Printing chemical libraries on microarrays for fluid phase nanoliter reactions: D.N. Gosalia, et al.; Proc. Natl. Acad. Sci. U. S. A.
100, 8721 (2003),
Abstract;
Full Text
