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Caspase-10 (human), (recombinant)

BML-SE174-5000 5000 U 531.00 USD
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Product Details

Alternative Name:FLICE2, Mch4
MW:17 + 12 kDa
Source:Produced in E. coli.
UniProt ID:Q92851
Formulation:Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.1% CHAPS, 1mM EDTA, 10% glycerol, 10mM DTT.
Purity:≥95% (SDS-PAGE)
Activity:100 U/µl
Specific Activity:One U=1pmol/min using Ac-IETD-pNA (200µM; Prod. No. ALX-260-045) as substrate at 30°C.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:Caspase-10 is an initiator caspase, highly homologous to caspase-8, a relationship that extends to the death effector domains (DEDs) of their proforms. Caspase-10 was reported to activate early in TRAIL-induced apoptosis and was found in association with the DR4 (TRAIL-R1) receptor complex in a thyroid carcinoma line.
Regulatory Status:RUO - Research Use Only

Product Literature References

Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death: M. Cho, et al.; J. Autoimmun. 133, 102940 (2022), Abstract;