Product Details
| Alternative Name: | FLICE2, Mch4 |
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| MW: | 17 + 12 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | Q92851 |
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| Formulation: | Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.1% CHAPS, 1mM EDTA, 10% glycerol, 10mM DTT. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Activity: | 100 U/µl |
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| Specific Activity: | One U=1pmol/min using Ac-IETD-pNA (200µM; Prod. No. ALX-260-045) as substrate at 30°C. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Caspase-10 is an initiator caspase, highly homologous to caspase-8, a relationship that extends to the death effector domains (DEDs) of their proforms. Caspase-10 was reported to activate early in TRAIL-induced apoptosis and was found in association with the DR4 (TRAIL-R1) receptor complex in a thyroid carcinoma line. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death: M. Cho, et al.; J. Autoimmun.
133, 102940 (2022),
Abstract;
