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Caspase-11 (mouse), (recombinant)

BML-SE155-5000 5000 U 531.00 USD
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Product Details

MW:23 + 10 kDa subunits
Source:Produced in E. coli. Mouse caspase-11 (aa 81-373).
UniProt ID:P70343
Formulation:Liquid. In 50mM HEPES, pH 7.4, 100mM NaCl, 0.5% CHAPS, 1 mM EDTA, 10% glycerol, 10mM DTT.
Purity:≥95% (SDS-PAGE)
Activity:100 U/µl
Specific Activity:One unit hydrolyzes 1 pmol/min of Ac-WEHD-pNA (500 µM, Prod. No. ALX-260-082) at 30°C.
Shipping:Dry Ice
Long Term Storage:-80°C
Scientific Background:A member of the caspase-1 subfamily, caspase-11 is the possible homolog of human caspase-4. Its expression is highly inducible, in various mouse tissues, by LPS injection.
Regulatory Status:RUO - Research Use Only
Caspase-11 (mouse), (recombinant) SDS-PAGE
SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 μg, Lane 2: 2 μg Caspase-11.
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Caspase-11 (mouse), (recombinant) SDS-PAGE

Product Literature References

Cathepsin G inhibition by serpinb1 and serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation: S.S. Burgener, et al.; Cell Rep. 27, 3646 (2019), Abstract;

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