Substrate for farnesyltransferase (>25%) with Km~4 µM using rat brain FT. Possesses GDP binding at >1:4 GDP/H-ras.
Product Details
| MW: | 28 kDa |
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| Source: | Produced in E. coli. |
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| UniProt ID: | P01112 |
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| Formulation: | Liquid. In 20mM TRIS-HCl, pH 8.0, containing 45mM sodium chloride, 1mM DTT, 5mM magnesium chloride and 50% glycerol. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Purity Detail: | Purified by multi-step chromatography. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE Analysis: Lane 1: MW Marker, Lane 2: 1 μg, Lane 3: 2 μg, Lane 4: 5 μg Ras.
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Product Literature References
Multivalent Small-Molecule Pan-RAS Inhibitors: M.E. Welsch, et al.; Cell
168, 878 (2017),
Abstract;
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