Product Details
| Alternative Name: | Leukocyte common antigen-related protein tyrosine phosphatase |
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| MW: | 37 kDa |
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| Source: | Produced in E. coli. Soluble catalytic LAR-D1 domain (350 aa). |
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| UniProt ID: | P10586 |
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| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.0, containing 100mM sodium chloride, 2mM EDTA, 5mM dithiothreitol, 0.01% Brij 35, and 30% glycerol. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Purity Detail: | Contains no detectable protease, DNase, RNase, or Ser/Thr phosphatase activity. |
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| Specific Activity: | ≥3 U/µg. One unit will hydrolyze 1 nmol p-nitrophenyl phosphate per minute at pH 7.0 and 30°C. 20 U can dephosphorylate >95% of phosphotyrosine in 1 nmol protein in 30 minutes. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Removes phosphate specifically from tyrosine residues in proteins. Rate of dephosphorylation depends on LAR substrate preference. |
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| Regulatory Status: | RUO - Research Use Only |
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SDS‐PAGE Analysis: Lane 1: MW Marker, Lane 2: 1μg LAR protein tyrosine phosphatase (human), (recombinant)
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Product Literature References
The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues: N.L. Cook, et al.; Free Radic. Biol. Med.
90, 195 (2016),
Abstract;
