Specifically ablates zebrafish larval melanocytes. This melanocytotoxicity is dependent on tyrosinase activity. A useful tool for elucidating melanocyte stem cell regeneration, recruitment and maintenance mechanisms.
Product Details
| Alternative Name: | 4-(4-Morpholinobutylthio)phenol |
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| Formula: | C14H21NO2S |
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| MW: | 267.4 |
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| CAS: | 57055-82-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at +20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes: K. Hultman et al.; PLoS Genetics
5, e1000544 (2009),
Abstract;
Full Text
Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish: C.T. Yang et al.; PLoS Genetics
3, e88 (2007),
Abstract;
Full Text
Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes: C.T. Yang et al.; Development
133, 3563 (2006),
Abstract;
Full Text
