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IDE-1

Induces stem cell differentiation
 
BML-SC100-0001 1 mg 117.00 USD
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Cell-permeable molecule capable of directing differentiation of mouse and human embryonic stem cells into endodermal cells (EC50=125nM). Developmental potential of these chemically derived endodermal cells has been shown via continued differentiation into pancreatic progenitor cells and incorporation into developing gut tubes of live mouse embryos. Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling pathway.

Product Specification

Alternative Name:7-(2-(2-Carboxybenzylidene)hydrazinyl)-7-oxoheptanoic acid, 2-[(6-Carboxyhexanoyl)hydrazonomethyl]benzoic acid
 
Formula:C15H18N2O5
 
MW:306.3
 
CAS:1160927-48-9
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25 mg/ml) or 100% ethanol (12 mg/ml with warming).
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Regulatory Status:RUO - Research Use Only
 
BML-SC100 Structure
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BML-SC100 Structure

Product Literature References

Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells: M. Borowiak, et al.; Cell Stem Cell 4, 348 (2009), Abstract;

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