Cell-permeable molecule capable of directing differentiation of mouse and human embryonic stem cells into endodermal cells (EC50=125nM). Developmental potential of these chemically derived endodermal cells has been shown via continued differentiation into pancreatic progenitor cells and incorporation into developing gut tubes of live mouse embryos. Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-β-signaling pathway.
Product Details
| Alternative Name: | 7-(2-(2-Carboxybenzylidene)hydrazinyl)-7-oxoheptanoic acid, 2-[(6-Carboxyhexanoyl)hydrazonomethyl]benzoic acid |
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| Formula: | C15H18N2O5 |
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| MW: | 306.3 |
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| CAS: | 1160927-48-9 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25 mg/ml) or 100% ethanol (12 mg/ml with warming). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells: M. Borowiak, et al.; Cell Stem Cell
4, 348 (2009),
Abstract;
