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Melanocortin receptor 2 (extracellular) polyclonal antibody

BML-SA639-0050 50 µl 379.00 USD
BML-SA639-0200 200 µl 680.00 USD
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Product Specification

Alternative Name:MC2R
Immunogen:Synthetic peptide corresponding to aa 87-99 of human MC2R (melanocortin receptor 2).
UniProt ID:Q01718
Species reactivity:Human, Rat
Applications:IHC, WB
Blocking Peptide:Included. Synthetic peptide corresponding to aa 87-99 of human MC2R (melanocortin receptor 2). Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C. Reconstitute with 100µl water and store at -20°C. Use 1µg peptide per 1μg antibody.
Purity Detail:Affinity purified.
Formulation:Lyophilized from PBS, pH 7.4, containing 1% BSA and 0.05% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The melanocortin receptors are members of the G protein-coupled receptor superfamily. Their ligands, the melanocortins, are peptides consisting of α-, β- and γ-melanocyte stimulating hormone and adrenocorticotropic hormone. MC2R is only activated by ACTH. It is expressed gene is expressed in skin, scalp tissue, compound nevus tissue, basal cell carcinoma tissue, and cultured melanocytes.
Regulatory Status:RUO - Research Use Only

Product Literature References

Expression of melanocortin receptors in human prostate cancer cell lines: MC2R activation by ACTH increases prostate cancer cell proliferation: S. Hafiz, et al.; Int. J. Oncol. 41, 1373 (2012), Application(s): Immunofluorescence, Abstract; Full Text

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